A half-century of neglecting fragilities in production and a confluence of disruptions have brought us to this point. At least once over the past 18 months, when you tried to order something online or visited a retail store, you have probably experienced something Americans are not supposed to feel: scarcity. Shortages of all kinds have lingered and even worsened over the past 18 months, in every product imaginable: Hot tubs, automobiles, books, fertilizer, plastic pipettes for labs, paint, semiconductor chips, place mats, french fries at Burger King, emergency supplies for disaster aid, aluminum cans, and yes, once again, toilet paper. One might have assumed that, after the worst lockdowns of 2020 ended, these disruptions would subside, and supply chains would ramp back up to their usual pace. And one could further have assumed that supply would catch up to spikes in demand once mass vaccinations began. But it takes time to untangle something that becomes so tangled, time for a shortage on one side of the world to appear on the other. There are manufacturing plants and ships and ports and containers and airplanes and trucks and trains and warehouses and retail locations that all have to be managed just right, and just in time, under our current nothing-in-excess style of how we get only as many goods as we need in any one location. The supply snarls we’re seeing today are a function of those previous lockdowns, misaligned inventories of things like shipping containers, continued COVID protections that extend manufacturing and shipping delays, and extreme weather. But more important than all of these is the state of global production. With its thin margins and consolidated structure, the globalization of production magnifies disruptions of any type. This is why getting what you desire when you desire it is no longer a certain bet. And we haven’t even really begun to grapple with this problem, despite a cataclysmic pandemic that should have shaken us into shape.

"We need immigration in our industry to continue to have enough team members," Domino's Pizza CEO Ritch Allison told CNBC's Jim Cramer.

Edible dormice were a delicacy in ancient Rome. They were fattened in cages before being gutted, skinned and stuffed with pork mince, ground pine nuts and garlic and then baked.

DNA is modified by the addition of chemical groups. Methylation, when a methyl group is added, is the form of DNA modification that has been studied most, but DNA can also be tagged with hydroxymethyl groups, and proteins in the chromatin complex can be modified too.

Huge architectural gems built deep into the Earth like inverted fortresses are scattered around India – and restoring them may be a solution to help the country's parched communities.

The covid patient in Room 107 was bleeding internally and near death. So Robin Pressley, transfer coordinator at Stillwater Medical Center, was working fast to try to find an ICU bed at a larger hospital for Johnnie Novotny, a 69-year-old retired gas plant operator who had developed a hematoma and needed more specialized care than doctors at this modest rural hospital could provide. Pressley knew that other hospitals in the region were already choked with covid patients due to a summer surge driven by the highly infectious delta variant and the state’s large numbers of unvaccinated residents, like Novotny. But she also knew that Novotny’s life depended on her success. After 34 years in nursing, Pressley had developed ways to deal with the stress of her job. So, on this August day, she loaded her diffuser with calming lemongrass oil and pulled out a piece of putty she uses as a makeshift stress ball and began squeezing. Then she fired up her two computer screens, picked up one of her three phones, and started dialing.

A deadly bow and arrow attack in Norway which left five people dead appears to have been an act of terror, Norway's security service (PST) said. The suspect, a 37-year-old Danish citizen named Espen Andersen Brathen, had converted to Islam and there were fears he had been radicalised. However a motive has not yet been determined. He is accused of killing four women and a man on Wednesday night in the southern town of Kongsberg. In a press release on Thursday (in Norwegian), police said Brathen was due to appear in court on Friday at 09:00 local time (07:00 GMT). A police lawyer told public broadcaster NRK he would be assessed by psychiatrists. During a press conference PST head Hans Sverre Sjovold said the suspect had been "in and out of the health system for some time". Residents have been deeply shaken by the violence. Flags were flown at half-mast on Thursday while flowers and other memorials were placed in Kongsberg's main square. The victims were all aged between 50 and 70, regional police chief Ole Bredrup Saeverud told reporters at a Thursday morning news briefing. The attack was first reported at 18:13 (16:13 GMT) on Wednesday. Police confronted the man six minutes later, but he shot several arrows at them and escaped. He was eventually caught about 30 minutes later. It was during this time, between being first approached and then arrested, that the victims were killed, the police chief said.

There’s demand for vaccines again. That’s the good news. The surge is thanks to boosters, mandates and, literally, the fear of death (and Delta).  The bad news: We still haven’t addressed conditions that made it so hard for some communities to get shots in the first place.  That’s when they turn to Epicenter, so we’re back to helping neighbors who don’t have cell phones, internet connectivity, primary care doctors, legal status, time off from work, English skills, a grasp of the science behind vaccines, patience to deal with chain-pharmacy-website registrations, among other challenges.  Based on the last few months of these requests and our work on the ground in undervaccinated Queens Village, we’re seeing a handful of trends. We share them below, along with some possible solutions.

The Board of Regents for the University System of Georgia approved a new posttenure review policy Wednesday without discussion, despite statewide faculty opposition to the plan. The board’s academic affairs committee approved the changes Tuesday during the first day of the two-day regents’ meeting, prior to the full board’s approval. Faculty members from across the 26-institution system had urged the board to change course, warning that the changes -- which decouple posttenure review from existing dismissal policies and their due process protections, and which add “student success” to the criteria by which faculty members are evaluated -- will hurt academic freedom and the system’s reputation. The university system made some changes to the policy proposal before the board approved the final language, but faculty members said those updates were mostly superficial. The national office of the American Association of University Professors has committed to investigating the system for adopting the...

The Clean Electricity Performance Program, the cornerstone climate policy in Democrats' massive social safety net package, will likely be dropped from the final budget deal after pushback from Sen. Joe Manchin of West Virginia, three congressional sources told CNN.

“I’m not into golden showers,” the former president blurted out to the crowd.

Bots have made it nearly impossible to buy hyped up shoes. What if they could be stopped?

“[Gay bars] would just be a good place to go,” he said. “Everybody was chill, everybody. You didn’t really have to sort of state your sexuality. It was OK. And it was a very safe place to be. And I could meet girls there, cos there are a lot of girls there for exactly the same reason I was there. It was kind of an ulterior motive.”

WASHINGTON (AP) — A U.S. Capitol Police officer has been indicted on obstruction of justice charges after prosecutors say he helped to hide evidence of a rioter's involvement in the Jan. 6 insurrection.

Overheard comment suggests anger at possible no-shows at Cop26 by leaders of countries with worst CO2 emissions

A federal grand jury in Texas on Thursday indicted Mark Forkner, 49, Boeing’s former chief technical pilot on the 737 MAX program, charging him with fraud. This is the only criminal charge so far resulting from a Department of Justice investigation into two deadly MAX crashes that killed 346 people in Indonesia and Ethiopia. The government reached a Deferred Prosecution Agreement with Boeing in January, in which the company acknowledged fraud and criminal misconduct during certification of the MAX. The DPA slapped Boeing with a relatively small fine of $244 million and specifically exonerated Boeing’s senior management by stating that they had not facilitated the misconduct. However, the agreement cited Forkner and his deputy as being involved... The prosecution agreement, criticized for the way it let Boeing executives off the hook, was filed by the then-U.S. Attorney in the northern district of Texas, Erin Nealy Cox. Cox left the Department of Justice after the agreement and in June joined Kirkland & Ellis, Boeing’s lead corporate criminal defense law firm. On Kirkland’s website, she was welcomed to the firm as a partner by Mark Filip, who had signed the DPA on behalf of Boeing.

Man arrested on suspicion of murder after Conservative MP attacked during regular surgery in Leigh-on-Sea in Essex

The extensive allegations present a portrait of an environment inside the state’s juvenile prisons that is rife with physical attacks.

At least part of the standstill over Democrats’ $3.5 trillion reconciliation bill...

The future of four-legged warfare.